optomap fa in Progression to PDR

Researchers from a clinical study published in JAMA Ophthalmology used optomap fa imaging to measure the amount of non-perfusion in patients with NPDR and PDR


Results indicate that the total area of retinal nonperfusion, specifically in the periphery, is greater in eyes with proliferative diabetic retinopathy (PDR) than in eyes with non-proliferative diabetic retinopathy (NPDR).  It was found that eyes with at least 107.3 disc areas (DA) of retinal non-perfusion are at risk for proliferative diseases.  The study also found that eyes with neovascularization of the disc (NVD) had larger areas of non-perfusion.

A second study more recently published, found similar results with 77.48mm being associated with an increased risk of progression to PDR.

These findings suggest that optomap fa imaging may improve clinician’s ability to identify signs of diabetic retinopathy progression.

Findings in this study are consistent with previous research which determined that the presence of peripheral lesions increase a patient’s risk of progressing to PDR by a factor of 4.7 and that approximately 70% of non-perfusion occurs outside of the poster pole. OptosAdvance software allows for the registration of images and monitoring patient’s progression over time. Non-perfusion areas can be quantified and compared between visits.

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