Case Study: Angiomatous Proliferation in ROP Using optomap®

A 15 year-old African American female with a history of bilateral threshold retinopathy of prematurity was seen for a routine annual visit. As an infant, she was treated with scatter laser photocoagulation two months after her birth. At this visit, she was asymptomatic with a visual acuity of 20/25 in the right eye and 20/15 in the left eye.






optomap® color images were obtained and showed a reddish orange, slightly elevated lesion at 2 o’clock in the far periphery of the right eye, anterior to the equator. Images also confirmed areas of previous laser treatment in the temporal periphery. optomap fluorescein angiogram images were obtained and showed the lesion to be hyperfluorescent and that the lesion had feeding and draining retinal vessels. The left eye did not have similar lesions, but did have evidence of previous laser treatment in the temporal periphery.




optomap color and fluorescein angiography were used to document the appearance and investigate the characteristics of the peripheral lesion. The lesion was determined to be reactive angiomatous proliferation – a rare vascular proliferation which has been reported to occur in various chronic retinal diseases, such as retinitis pigmentosa and Coats’ disease. Most recently, it has been reported to have occurred in a 14 year-old female with a remote history of retinopathy of prematurity, similar to our patient. She underwent cryotherapy to the lesion, and early involution of the lesion was present one month following treatment.




Researchers, Anna Gabrielian, MD and Mathew W. MacCumber, MD, PhD, concluded that optomap color and fa widefield imaging successfully captured, documented, and allowed the investigation of this rare vasoproliferative condition.


Make optomap part of your practice to enable you to See More. Treat More Effectively™. To find out more about our contact us to learn how partnering with Optos can enhance your patient care.