Ultra-wide-field angiography improves the detection and classification of diabetic retinopathy.

Compared with conventional 7SF imaging, ultra-wide-field fluorescein angiography reveals significantly more retinal vascular pathology in patients with diabetic retinopathy. Improved retinal visualization may later the classification of diabetic retinopathy and may therefore influence follow-up and treatment of these patients.

Kiss et al. Retina.


Panoramic Autofluorescence: Highlighting Retinal Pathology.

Autofluorescent ophthalmoscopy is a non-invasive procedure that can detect changes in metabolic activity at the retinal pigment epithelium before clinical ophthalmoscopy. Peripheral retinal abnormalities may precede central retinal impacts, potentially providing early signs for intervention before impacting visual acuity. The panoramic image enhances clinical pattern recognition over a large area and in comparison between eyes.

Sherman et al. Optometry and Vision Science, Vol. 89, No. 5


Peripheral retinal ischaemia, as evaluated by ultra-widefield fluorescein angiography, is associated with diabetic macular oedema

Retinal ischaemia is significantly correlated with DMO in treatment-naïve patients with DR. UWFA is a useful tool for detecting peripheral retinal ischaemia, which may have direct implications in the diagnosis, follow-up and treatment such as targeted peripheral photocoagulation.

Kiss et al. Br J Ophthalmol.


Ultra-wide Field Retinal Imaging in Detection, Classification, and Management of Diabetic Retinopathy.

When compared with mydriatic ETDRS-protocol, 7 standard field photographs and clinical examination, nonmydriatic UWF images appear to have excellent agreement in allowing the detection and classification of diabetic retinopathy (DR), althought larger, definitive validation studies are stil forthcoming. UWF imaging and angiography allow visualization of peripheral retinal nonperfusion, vascular leakage and neovascularization in patients with DR that may not be captured on 7 standard fields. 

Sun et al. Seminars in Ophthalmology, 27(5-6), 221-227, 2012.


Ultra-wide-field autofluorescence imaging in non-traumatic rhegmatogenous retinal detachment.

UWF-AF imaging reveals abnormalities in RRDs that allow excellent demarcation of the extent of the retinal detachment and assist in preoperative characterization of the detachment and postoperative counselling. 

Kiss et al. Eye (Lond). 


Comparison of wide-field fluorescein angiography and 9-field montage angiography in uveitis. 

More retinal vascular pathology, in both the periphery and the posterior pole, is seen with Optos FA in patients with uveitis when compared with 9-field montage. 

Nicholson. Am J Ophthalmol. 


Noncontact High-Resolution Ultra-Wide-Field Oral Fluorescein Angiography in Premature Infants With Retinopathy of Prematurity.

Noncontact ultra-wide-field oral fluorescein angiograms captured using the Optos Panoramic 200MA fluorescein angiographic system provide a safe and alternative method for evaluating the retinal vasculature in premature infants with retinopathy of prematurity.

Patel et al. JAMA Ophthalmol.


Peripheral Autofluorescence and Clinical Findings in Neovascular and Non-neovascular Age-related Macular Degeneration.

Several distinct patterns of peripheral FAF abnormalities were observed in 68.9% of patients, with AMD type, female gender, and age being independent risk factors. The peripheral FAF patterns correlate strongly with specific clinical features seen in eyes with AMD.

Sadda et al. Ophthalmology.


Patterns of peripheral retinal and central macula ischemia in diabetic retinopathy as evaluated by ultra-widefield fluorescein angiography.

Ultra-widefield fluorescein angiography provides an insight into the relationships between diabetic vascular complications in the retinal periphery and central macula. Although we observed relationships between ischemia and vascular leakage in the macula and periphery, it was only macular ischemia and retinal thinning that was independently associated with a reduced visual function.

Sim et al. Am J Ophthalmol.


Potential efficiency benefits of nonmydriatic ultrawide field retinal imaging in an ocular telehealth diabetic retinopathy program. 

In a standardized DR ocular telehealth program, nonmydriatic UWFI reduced the ungradable rate by 71% (to <3%) and reduced image evaluation time by 28%. DR was identified 17% more frequently after UWFI, and DR peripheral lesions suggested a more severe DR level in 9%.

Aiello et al. Diabetes Care.