Optos was founded and incorporated in 1992 by Douglas Anderson after his then five-year-old son went blind in one eye when a retinal detachment was detected too late. Although his son was having regular eye exams, routine exams were uncomfortable, especially for a child, which made it impossible for the doctor to conduct a complete exam and view the entire retina. Anderson set out to commercialize a patient-friendly retinal image product that encompassed a digital widefield image of the retina in a single capture.

In 1999 the P200 received both 510k clearance from the FDA and the EU CE marking, and full commercial launch occurred in the UK and US in 2000 with sales in Canada from 2003 and Germany from 2004. Subsequently the devices have been sold or placed in Austria, Switzerland, France, Spain, Norway and Sweden with some limited penetration in Korea, China and Australia.

The Company was financed through angel and venture capital investors until its flotation on the London stock Exchange in February 2006. In May 2015, Optos was acquired by Nikon.